Endocrine Abstracts

Background: Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent in children and young people (CYP), mainly linked to the rise in obesity. It is associated with higher and earlier risk of developing complications; therefore, prompt diagnosis and management involving the multidisciplinary team (MDT) is crucial. The aim of our study was to evaluate the current practice for T2DM management and monitoring of complications at our centre.Methods:...

Introduction: Trimethylaminuria or Fish Odour syndrome is a rare genetic metabolic disorder. It can cause significant suffering to affected individuals due to social isolation and stigma. It is under recognised and ignored.The case: A 60 years old lady was referred by her GP. The referral – ‘She feels she has a problem with personal hygiene and is aware of an odour from her skin, her breath and urine.’ This lady has been suffering from thi...

38 year female presented to the endocrine clinic with palpitations. On further questioning she reported weight loss, diarrhoea but normal menstrual cycles. She was diagnosed in September 2022 with thyrotoxicosis in a country outside UK and was commenced on carbimazole 20 mg once daily. Blood investigations in September 2022- TSH 0.02 serum FT4 31.0 FT3 8.17). Bloods repeated by GP 4 months later after arrival in UK, showed the following: Serum TSH 23.45, serum T4 1.20, serum T...

Introduction: Lymphocytic Hypophysitis (LH) is an autoimmune endocrinopathy characterised by extensive infiltration of the anterior pituitary gland with chronic inflammatory cells, thus causing pituitary expansion and a variable degree of hypopituitarism closely mimicking the features noted in pituitary adenoma and seen most frequently in women. The aetiology has a general preponderance of occurring at the end of gestation or during the early postpartum period.<p class="ab...

Introduction: Cataract development as a complication of diabetes is usually associated with increased age and longer duration of diabetes. However, rapidly progressive cataracts have also been described at, or soon after, diagnosis of type 1 diabetes (T1DM). We report two cases of adolescents with T1DM and bilateral cataracts, including one case in which visual loss was the presenting symptom.Cases: A 16-year old non-obese, caucasian boy presented to his...

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT is commonly used to investigate PHPT. Our centre previously published sensitivity and specificity of 92 and 86% respectively for Tc99m-Sestamibi+I-123 subtraction. Five false-negative studies required neck exploratory surgery. One false-positive study incorrectly localised a PA which was not found in surgery (n=67). In recent years 4D-CT parathyroid has emerged as a useful technique to detect an...

Background: Approximately a third of pregnant women in the UK are Vitamin D deficient, which may confer deleterious consequences, including an increased risk of pre-eclampsia, gestational diabetes mellitus, and intrauterine growth restriction. Vitamin D supplementation in pregnancy has shown to be beneficial, including a reduced risk of pre-eclampsia and pre-term birth, compared to placebo. This audit investigated the extent to which women attending an ante-natal centre adhere...

We present a rare case of a 50 years old lady who presented with new onset hirsutism and hoarseness of voice since 2 years. Investigations showed high serum testosterone, androstendione and free androgen index. All other systemic and endocrinology evaluation for hirsutism did not reveal any abnormality. CT scan of her abdomen showed a right ovarian mass which was confirmed as a Sertoli-Leydig cell tumour (stage Ia) on surgical staging and completely cured after bilateral salpi...

We present the case of a 50-year-old lady who initially presented to the endocrine department at Royal Bolton Hospital in 2011 with symptoms of tiredness and lethargy following hysterectomy and bilateral salpingo-oophorectomy in 2003. Hormone replacement therapy was not commenced in view of a strong family history of breast cancer. There is a family history of both autoimmune hypothyroidism and hyperthyroidism. Thyroid function tests were normal, with a positive thyroid peroxi...

Introduction: X-linked hypoparathyroidism is an extremely rare disease, so far described in only two multigenerational kindreds. In US, who later on the genetic testing were found to be interrelated. W describe X-linked congenital hypoparathyroidism in a family from India.Case report: Case 1 presented with hypocalcaemic non-febrile generalised tonic clonic seizures at 16 months of age. Seizures controlled after hypocalcaemia correction. He was put on T. ...